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Objec�ves •Evaluate feasibility of POC newborn screening using HemoTypeSC in rural Tabora primary healthcare facilities Assess prevalence of SCD and carrier states in the screened population (1). Compare rapid tests results with Gazelle Hb electrophoresis for confirmatory accuracy. (2). Establish a referral and follow up model connecting infants with SCD to care
Background: Sickle cell disease (SCD) is the most common life-threatening monogenic disorder globally (1). Tanzania is the fifth-highest burden country for SCD, with prevalence of SCD (HbSS) ranging between 0.8% – 1.4%, and prevalence of sickle cell trait (HbAS) ranging from 13% in coastal regions to 20% in Lake Zone regions (2). Without comprehensive care, SCD is associated with high morbidity and mortality (1-3), accounting for 7% of deaths among children under five in Tanzania (2). Early diagnosis and enrolnment into comprehensive care significantly reduce the mortality and improve the health-related outcomes among children with SCD.